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- Vasiliki Tsolaki and George E Zakynthinos.
- Department of Intensive Care Medicine, General University of Larissa, University of Thessaly, Faculty of Medicine, Larissa, Thessaly, Greece. Electronic address: vasotsolaki@yahoo.com.
- Br J Anaesth. 2022 Aug 1; 129 (2): 150-153.
AbstractComputational modelling has been used to enlighten pathophysiological issues in patients with acute respiratory distress syndrome (ARDS) using a sophisticated, integrated cardiopulmonary model. COVID-19 ARDS is a pathophysiologically distinct entity characterised by dissociation between impairment in gas exchange and respiratory system mechanics, especially in the early stages of ARDS. Weaver and colleagues used computational modelling to elucidate factors contributing to generation of patient self-inflicted lung injury, and evaluated the effects of various spontaneous respiratory efforts with different oxygenation and ventilatory support modes. Their findings indicate that mechanical forces generated in the lung parenchyma are only counterbalanced when the respiratory support mode reduces the intensity of respiratory efforts.Copyright © 2022 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.
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