• Frank Bloos, Jürgen Held, Stefan Kluge, Philipp Simon, Klaus Kogelmann, Geraldine de Heer, Sven-Olaf Kuhn, Dominik Jarczak, Johann Motsch, Gunther Hempel, Norbert Weiler, Andreas Weyland, Matthias Drüner, Matthias Gründling, Patrick Meybohm, Daniel Richter, Ulrich Jaschinski, Onnen Moerer, Ulf Günther, Dirk Schädler, Raphael Weiss, Christian Putensen, Ixchel Castellanos, Oliver Kurzai, Peter Schlattmann, Oliver A Cornely, Michael Bauer, Daniel Thomas-Rüddel, and SepNet Study Group.
• Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany. frank.bloos@med.uni-jena.de.
• Intensive Care Med. 2022 Jul 1; 48 (7): 865875865-875.

PurposeTo investigate whether (1 → 3)-β-d-Glucan (BDG)-guidance shortens time to antifungal therapy and thereby reduces mortality of sepsis patients with high risk of invasive Candida infection (ICI).MethodsMulticenter, randomized, controlled trial carried out between September 2016 and September 2019 in 18 intensive care units enrolling adult sepsis patients at high risk for ICI. Patients in the control group received targeted antifungal therapy driven by culture results. In addition to targeted therapy, patients in the BDG group received antifungals if at least one of two consecutive BDG samples taken during the first two study days was ≥ 80 pg/mL. Empirical antifungal therapy was discouraged in both groups. The primary endpoint was 28-day-mortality.Results339 patients were enrolled. ICI was diagnosed in 48 patients (14.2%) within the first 96 h after enrollment. In the BDG-group, 48.8% (84/172) patients received antifungals during the first 96 h after enrollment and 6% (10/167) patients in the control group. Death until day 28 occurred in 58 of 172 patients (33.7%) in the BDG group and 51 of 167 patients (30.5%) in the control group (relative risk 1.10; 95% confidence interval, 0.80-1.51; p = 0.53). Median time to antifungal therapy was 1.1 [interquartile range (IQR) 1.0-2.2] days in the BDG group and 4.4 (IQR 2.0-9.1, p < 0.01) days in the control group.ConclusionsSerum BDG guided antifungal treatment did not improve 28-day mortality among sepsis patients with risk factors for but unexpected low rate of IC. This study cannot comment on the potential benefit of BDG-guidance in a more selected at-risk population.© 2022. The Author(s).

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