• Daniel Kobewka, Tayler Young, Tolu Adewole, Dean Fergusson, Shannon Fernando, Tim Ramsay, Maren Kimura, and Pete Wegier.
• Investigator, Bruyere Research Institute, Ottawa, ON, Canada; Clinician Investigator, The Ottawa Hospital Research Institute, Ottawa, ON, Canada. Electronic address: dkobewka@toh.ca.
• Resuscitation. 2022 Sep 1; 178: 45-54.

AimOur aim was to determine the association of cardiopulmonary resuscitation (CPR) for in hospital cardiac arrest (IHCA) with quality of life after discharge.MethodsWe performed a systematic review using available databases for studies that measured any quality-of-life or functional outcome both before and after CPR for IHCA. All screening and data abstraction was performed in duplicate.ResultsWe screened 10,927 records and included 24 papers representing 20 unique studies. Fifteen studies measured Cerebral Performance Category. Survival ranged from 11.8% to 39.5%. The risk of impaired cerebral function after discharged ranged from -16.1% (lower risk) to 44.7% increased risk of poor cerebral function after surviving to discharge. Four studies measured discharge to an institutional environment finding that the risk was increased by 18.2-72.2% among survivors. One study measured EQ-5D and found no difference pre and post CPR. One study measured performance of activities of daily living finding that survivors needed assistance with more activities after discharge.ConclusionOur review is limited by the lack of adjustment for confounders, including the baseline level of each outcome, in all included studies. Therefore, although risk for most outcomes was increased after discharge vs pre-admission we cannot be certain if this is a causal relationship.Copyright © 2022 Elsevier B.V. All rights reserved.

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