• Douglas B White, J Randall Curtis, Leslie E Wolf, Thomas J Prendergast, Darren B Taichman, Gary Kuniyoshi, Frank Acerra, Bernard Lo, and John M Luce.
• University of California, San Francisco, and San Francisco General Hospital, San Francisco, California 94143-0903, USA. dwhite@medicine.ucsf.edu
• Ann. Intern. Med. 2007 Jul 3;147(1):34-40.

BackgroundPhysicians in intensive care units have withdrawn life support in incapacitated patients who lack surrogate decision makers and advance directives, yet little is known about how often this occurs or under what circumstances.ObjectiveTo determine the proportion of deaths in intensive care units that occur in patients who lack decision-making capacity and a surrogate and the process that physicians use to make these decisions.DesignMulticenter, prospective cohort study.SettingIntensive care units of 7 medical centers in 2004 to 2005.Patients3011 consecutive critically ill adults.MeasurementsAttending physicians completed a questionnaire about the decision-making process for each incapacitated patient without a surrogate or advance directive for whom they considered limiting life support.ResultsOverall, 5.5% (25 of 451 patients) of deaths in intensive care units occurred in incapacitated patients who lacked a surrogate decision maker and an advance directive. This percentage ranged from 0% to 27% across the 7 centers. Physicians considered limiting life support in 37 such patients or would have considered it if a surrogate had been available. In 6 patients, there was prospective hospital review of the decision, and in 1 patient, there was court review. In the remaining 30 patients, the decision was made by the intensive care unit team alone or by the intensive care unit team plus another attending physician. The authors found wide variability in hospital policies, professional society guidelines, and state laws regarding who should make life-support decisions for this patient population. Thirty-six of 37 life-support decisions were made in a manner inconsistent with American College of Physicians guidelines for judicial review.LimitationsThe results are based on physicians' self-reported practices and may not match actual practices. The number of incapacitated patients without surrogates in the study is small.ConclusionsIncapacitated patients without surrogates accounted for approximately 1 in 20 deaths in intensive care units. Most life-support decisions were made by physicians without institutional or judicial review.

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