• Patrícia Leão da Silva, Marco Túlio de Mello, Nadia Carla Cheik, Priscila Lima Sanches, Fabíola Alvise Correia, Aline de Piano, Flávia Campos Corgosinho, Raquel Munhoz da Silveira Campos, Claudia M O do Nascimento, Lila M Oyama, Lian Tock, Sérgio Tufik, and Ana R Dâmaso.
• Post Graduate Program of Nutrition, Universidade Federal de São Paulo, São Paulo, Brazil. patricia.leao@cepebr.org
• Pediatr. Pulmonol. 2012 Jan 1;47(1):8-17.

BackgroundThe simultaneous rise in the prevalence of asthma and obesity in the world, have demonstrated the importance of the development of treatment strategies. The purpose of this study was to evaluate the short- and long-term results of interdisciplinary therapy on inflammatory biomarkers and lung function in asthmatics obese adolescents.MethodsSeventy-six post-pubertal obese adolescents were recruited, including 50 non-asthmatics [body mass index (BMI), 36 ± 5 kg/m(2) ) and 26 asthmatics (BMI, 39 ± 4 kg/m(2) ). Body composition was measured by plethysmography, and visceral fat was analyzed by ultrasound. Serum levels of adiponectin, leptin, and C-reactive protein (CRP) were analyzed. Asthma and lung function were evaluated according to the American Thoracic Society criteria. Patients were submitted to 1-year weight loss interdisciplinary intervention consisting of medical, nutritional, exercise, and psychological therapy.ResultsAfter interdisciplinary intervention, the lung function and pro/anti-inflammatory adipokines improved significantly in both groups. Most importantly, there was an increase in adiponectin [4 (1.86-12.9) to 5.1 (2.48-16)], a reduction in CRP [2,073 (385-9,174) to 1,538 (205-7,083)] and leptin concentrations [59 (29-69) to 33 (9-49)] in the asthmatics patients. Furthermore, it was observed a reduction in asthma severity after treatment. In addition, Δ adiponectin was an independent factor to improve lung function after therapy in both groups.ConclusionsInterdisciplinary therapy resulted in beneficial changes in inflammatory biomarkers profile and lung function in asthmatic and non-asthmatic obese adolescents. Additionally, for the first time we showed that change in adiponectin level was an independent predictor to improve lung function in Brazilian obese adolescents.Copyright © 2011 Wiley Periodicals, Inc.

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