• Transl Res · Dec 2022

    Review

    Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts.

    • Caitlin E Edwards, Aleksandra Tata, and Ralph S Baric.
    • Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
    • Transl Res. 2022 Dec 1; 250: 364536-45.

    AbstractHuman respiratory viruses induce a wide breadth of disease phenotypes and outcomes of varying severity. Innovative models that recapitulate the human respiratory tract are needed to study such viruses, understand the virus-host interactions underlying replication and pathogenesis, and to develop effective countermeasures for prevention and treatment. Human organoid models provide a platform to study virus-host interactions in the proximal to distal lung in the absence of a human in vivo model. These cultures fill the niche of a suitable ex vivo model that represents the in vivo lung environment and encapsulates the structure and function of the native human lung.Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

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