• Natalia de Oliva Spolidoro Paschoal, Jamil Natour, Flavia Soares Machado, Hilda Alcântara Veiga de Oliveira, FernandesArtur da Rocha CorreaADRCUniversidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil., and FurtadoRita Nely VilarRNVUniversidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil. Electronic address: rvfurtado@hotmail.com..
• Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
• Clinics (Sao Paulo). 2022 Jan 1; 77: 100036.

Objectiveto evaluate the effectiveness of triamcinolone Hexacetonide (TH) Intra-Articular Injection (IAI) in hand Interphalangeal Joints (IP) of Osteoarthritis (OA) patients to improve pain and joint swelling; improve function, goniometry, and grasping force, and assess IAI influence on radiographic evolution over 1-year.MethodsA randomized, double-blind study. 60 patients who underwent IAI at the most symptomatic IP joint were randomly assigned to receive TH+Lidocaine (LD) (TH/LD group) or just LD (LD group). Patients were assessed blindly for 1-year, at baseline and 1, 4, 8, 12, and 48 weeks. The following variables were assessed: articular pain and swelling, AUSCAN and COCHIN functional questionnaires, grip and pinch strength, goniometry, perception of improvement, acetaminophen consumption, and simple radiography. Repeated-measures ANOVA test was used to analyze the intervention response.ResultsSixty patients completed the follow-up. There were nine missed assessments. 97% were women; mean age of 61-years (SD = 8.2), and approximately 5-years of disease (SD = 3.6). Half of the patients present radiographic classification Kellgren and Lawrence (KL) grades I and II, and the other half grades III and IV. The two groups evolved similarly at 48-weeks. TH/LD group had a better evaluation in joint swelling and acetaminophen consumption (p = 0.04 and p < 0.001, respectively) at 48-weeks. Radiographically there was no statistical difference between groups (KL, p = 0.564; erosive OA, p = 0.999; worsening, p = 0.573).ConclusionThe IAI IP hands OA is effective for the improvement of joint swelling and decrease of analgesic consumption and does not influence the radiographic evolution of the injected joint.Copyright © 2022 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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