• Journal of neurotrauma · Dec 2022

    Rectal application of lidocaine reduces the severity of autonomic dysreflexia following experimental spinal cord injury.

    • Rahul Sachdeva, Tamila Kalimullina, Kiran Pawar, and Andrei Krassioukov.
    • International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.
    • J. Neurotrauma. 2022 Dec 1; 39 (23-24): 176417681764-1768.

    AbstractSpinal cord injury (SCI) results in devastating cardiovascular dysfunction. Noxious stimuli from the rectum during bowel routine often trigger life-threatening blood pressure surges, termed autonomic dysreflexia (AD). Rectal application of anesthetic lidocaine jelly has been recommended during bowel care to reduce AD severity by mitigating sensory input. However, clinical studies have reported contradicting evidence. We performed a pre-clinical study on the efficacy of rectal lidocaine in a standardized rodent T3 transection model. We found that 2% and 10% lidocaine significantly reduced AD severity by 32% and 50%, respectively, compared with control (p < 0.0001). Our pre-clinical experiments support the current recommendation of rectal lidocaine application during bowel care.

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