• Internal medicine · Mar 2023

    Case Reports

    A Case of Anti-SOX1 Antibody-positive Small-cell Lung Cancer that Triggered Opsoclonus.

    • Yuki Chiko, Yuka Sugisaki, Keiji Miyoshi, Daisuke Morichika, Yuka Beika, Akihiko Taniguchi, Eiki Ichihara, and Toshiaki Okada.
    • Department of Internal Medicine, Independent Administrative Agency, National Hospital Organization, Fukuyama Medical Center, Japan.
    • Intern. Med. 2023 Mar 15; 62 (6): 881884881-884.

    AbstractA 72-year-old woman with opsoclonus visited our hospital and was diagnosed with small-cell lung cancer. Blood tests revealed anti-SOX1 antibodies, so the patient was diagnosed with paraneoplastic opsoclonus-myoclonus syndrome. After steroid pulse therapy was started, chemotherapy of treatment, the opsoclonus showed an improving trend. Anti-Ri and anti-Hu antibodies have been reported as autoantibodies associated with neoplastic opsoclonus-myoclonus syndrome; however, there are no such reports concerning anti-SOX1 antibody. Therefore, this is a valuable case.

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