• Internal medicine · Jan 2023

    Review Case Reports

    New-onset Adult-onset Still's Disease Following COVID-19 Vaccination: Three Case Reports and a Literature Review.

    • Mayumi Matsuda, Funakubo AsanumaYuYDepartment of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan., Kazuhiro Yokota, Sakon Sakai, Hiroaki Yazawa, Takashi Maruyama, Takuma Tsuzuki Wada, Yasuto Araki, and Toshihide Mimura.
    • Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan.
    • Intern. Med. 2023 Jan 15; 62 (2): 299305299-305.

    AbstractSince December 2020, coronavirus disease 2019 (COVID-19) vaccines have been distributed in most countries to prevent the onset and aggravation of COVID-19. There is little information regarding the long-term safety of the vaccines. We report three cases and a literature review of new-onset adult-onset Still's disease (AOSD) that occurred following COVID-19 vaccination. Our cases include moderate to severe AOSD, and two were complicated with macrophage activation syndrome. Seventeen cases of new-onset or relapse of AOSD following COVID-19 vaccination, including 14 identified in the literature review and our 3 patients, were all treated successfully with glucocorticoid therapy, immunosuppressive drugs, or biologic agents.

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