• Maryam Khodashenas, Arezoo Rajabian, Armin Attaranzadeh, Fahimeh Lavi Arab, Negin Allahyari, and Abolghasem Allahyari.
• Mashhad University of Medical Sciences, Faculty of Medicine, Department of Internal Medicine - Mashhad, Iran.
• Rev Assoc Med Bras (1992). 2022 Jan 1; 68 (10): 136413681364-1368.

ObjectiveThis study aimed to assess the patterns of serum cytokines in chronic lymphocytic leukemia patients at baseline and post-chemotherapy and investigate their association with response to treatment and chronic lymphocytic leukemia prognosis.MethodsBlood samples were taken from 32 subjects at their first medical visit after being diagnosed with chronic lymphocytic leukemia and 1 year after chemotherapy. Then, levels of cytokines and blood parameters in peripheral blood were measured. Correlation analysis was used to assess the indexes before and after chemotherapy as well as at different disease stages.ResultsMost of the patients (45.80%) had stages I and III before initiation of treatment and after treatment, respectively. There were significant differences between levels of interleukin (IL)-6 (p=0.006) and IL-10 (p=0.009) before and after treatment. Notably, the difference in IL-10 levels before and after treatment was significantly higher in the advanced stages compared to that in the non-advanced stages (p=0.007). IL-6 and IL-10 were also higher in the expired patients compared to the survived cases.ConclusionsCytokines such as IL-6 and IL-10 may be considered predicting factors for chronic lymphocytic leukemia prognosis.

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