• Internal medicine · Jan 2010

    Comparative Study

    Relation between the estimated glomerular filtration rate and pulse wave velocity in Japanese.

    • Nobuyuki Miyatake, Kenichi Shikata, Hirofumi Makino, and Takeyuki Numata.
    • Department of Hygiene, Faculty of Medicine, Kagawa University, Japan. miyarin@med.kagawa-u.ac.jp
    • Intern. Med. 2010 Jan 1; 49 (14): 131513201315-20.

    ObjectiveWe investigated the link between renal function as evaluated by estimated glomerular filtration rate (eGFR) and pulse wave velocity (PWV) in Japanese without medications.MethodsA total of 1,244 Japanese subjects, aged 20-79 years, were recruited in a cross-sectional clinical investigation study. They received no medications. eGFR was calculated using serum creatinine (Cr), age and sex. Peripheral arterial stiffness was evaluated by brachial-ankle PWV (baPWV).ResultseGFR and baPWV were significantly correlated with age. eGFR was negatively correlated with baPWV (men: r=-0.308, p<0.0001, women: r=-0.293, p<0.0001). Twenty-six men (5.6%) and 35 women (4.5%) were diagnosed as reduced eGFR (eGFR <60 mL/min/1.73 m(2)). We compared clinical parameters between subjects with reduced eGFR (Group R) and without such reduction (Group N). baPWV in Group R was significantly higher than that in Group N even after adjusting for age. In women, systolic blood pressure in Group R was also significantly higher than that in Group N.ConclusioneGFR was closely associated with peripheral arterial stiffness in Japanese.

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