• Ons Fekih, Sonia Triki, Ilhem Hellara, Fadoua Neffati, Slaheddine Chouchane, Mohamed Neji Gueddiche, and Fadhel NajjarMohamedMHôpital Universitaire Fattouma Bourguiba, laboratoire de biochimie-toxicologie, 5000 Monastir, Tunisie..
• Hôpital Universitaire Fattouma Bourguiba, laboratoire de biochimie-toxicologie, 5000 Monastir, Tunisie; Hôpital Universitaire Fattouma Bourguiba, laboratoire de recherche « biologie moléculaire appliquée aux maladies cardiovasculaires, aux néphropathies et à la pharmacogénomique » LR12SP11, 5000 Monastir, Tunisie. Electronic address: onsfekihsallem@gmail.com.
• Presse Med. 2015 May 1; 44 (5): e185e190e185-90.

ObjectivesWe purpose to verify if paraoxonase 1 (PON1) activity may be a marker of cardiovascular risk in a young Tunisian population with type 1 diabetes (T1D).MethodsPON1 activity was measured by a kinetic method using paraoxon as substrate. The other parameters were determined by automated methods.ResultsOne hundred and nine children and adolescents with T1D and 97 healthy subjects were involved in this study. PON1 activity and PON1/HDL-cholesterol ratio were significantly decreased in diabetics (303 ± 174 vs. 372 ± 180 U/L and 221 ± 139 vs. 298 ± 20 1U/mmol, P=0.006, P=0.002, respectively) compared to controls. A significant increase in total cholesterol, LDL-c and microalbuminuria was observed in diabetics compared to controls. PON1 activity was decreased by 9.5% in patients with diabetes duration ≥ 6 years, by 28.4% for those with fasting glycemia ≥ 7 mmol/L (P<0.001), by 14% in those with HbA1c ≥ 8% and by 12.3% for diabetics with dyslipidemia. PON1 activity is reduced when the number of cardiovascular risk factors increases (P<0.001).ConclusionPON1 seems to be associated to cardiovascular risk markers in T1D. This result remains to be seen. Nevertheless, improving PON1 activity could be a significant target for reducing cardiovascular risk.Copyright © 2015 Elsevier Masson SAS. All rights reserved.

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