• M L González Castro, J Cordero Guevara, A Sáez Fernández, J Sagredo Pérez, E Arrojo Arias, and V del Saz Moreno.
• Centro de Salud San Agustín, Unidad Docente de Medicina Familiar y Comunitaria, Burgos.
• Aten Primaria. 1997 Sep 30; 20 (5): 221228221-8.

ObjectivesTo identify diabetics not dependent on insulin (DNDI) who are carriers of clinical proteinuria and microalbuminuria susceptible to captopril treatment and to evaluate the evolution of the urinary excretion of albumin (UEA) rate after three years of follow-up.DesignA prevalence study followed by an intervention and follow-up over 3 years.SettingThe urban Health Centre "San Agustín" in Burgos.Patients107 DNDI included in the "Diabetes programme".InterventionsPatients with increased UEA were treated with 25 mg of captopril (Capoten) every 12 hours for 3 years.Measurements And ResultsA steady drop in the UEA of patients with microalbuminuria was observed in their third year of treatment (p = 0.01). 5 patients (41.6%) became negative (p = 0.01).ConclusionsCaptopril treatment reduced levels of UEA in DNDI who had high UEA. Significantly, evolution to clinical proteinuria of patients with persistent microalbuminuria was avoided.

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