• John Hoon Rim, Yong-Ho Lee, Myung Ha Lee, Ha Yan Kim, Jiin Choi, Byung-Wan Lee, Eun Seok Kang, Hyun Chul Lee, Jeong-Ho Kim, Sang-Guk Lee, and Bong-Soo Cha.
• From the Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea (JHR, J-HK, S-GL), Department of Medicine (JHR), Department of Internal Medicine (Y-hL, B-WL, ESK, HCL, BSC), Department of Preventive Medicine (MHL), and Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea (HYK, JC).
• Medicine (Baltimore). 2016 Apr 1; 95 (14): e3230e3230.

AbstractLow-density lipoprotein cholesterol (LDL-C) is frequently estimated using the empirical Friedewald equation. We compared the accuracy of the novel equation named as the 180-cell method (180-c), which estimates LDL-C using a stratification approach, to those of 9 previously suggested formulas, including the Friedewald equation.We compared the accuracy of 10 equations by calculating intraclass correlation coefficient (ICC) and weighted kappa index in relation to direct LDL-C measurement values. Two independent populations used in the validation were the Severance Hospital LDL-C (SHL) registry (n = 164,358) and the Korea National Health and Nutrition Examination Survey (KNHANES) 2009 to 2010 (n = 3,854), each representing the hospital patient population and the general Korean population, respectively.The 180-c and DeLong equations showed the highest ICCs, indicating the best agreement with direct LDL-C measurement. The 180-c and Chen equations showed the highest kappa indices. For the hypertriglyceridemic subpopulation from SHL, the 180-c equation showed the best agreement with direct LDL-C measurement in terms of ICC.We compared the novel 180-c method for LDL-C estimation with 9 previous formulas in a non-US population as the first external validation. The 180-c equation, with Chen equation, appeared to be more accurate than the Friedewald equation. Although the DeLong equation showed better performance in the hypertriglyceridemic subpopulation, the 180-c equation performed appropriately in Asian population.

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