• Jana Mlíchová, Zoltán Paluch, and Ondřej Šimandl.
• Institute of Pharmacology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
• Pain Manag Nurs. 2023 Jun 1; 24 (3): 254264254-264.

ObjectivesThe aim of this review is to describe the effects of analgesics on sleep.Data SourcesSystematic search of the databases of PubMed and the Cochrane Library was performed between January and September 2021.Review/Analysis MethodsThe search included all articles on the topic published during the past 20 years (2000-2020). The search strategy was developed using a controlled vocabulary of known studies meeting the inclusion criteria and focused on the following terms: chronic pain, pain, sleep disturbance, insomnia, analgesic, analgesic medication, antidepressants, antiepileptic drugs, nonsteroidal drugs, opioids, and quality of life. Two reviewers independently considered the studies for inclusion in the review, assessed the risk of bias, and extracted data.DesignReview and analysis.ResultsA total of 37 studies met the inclusion criteria: 15 analyzed the effects of opioids, 6 those of nonsteroidal anti-inflammatory drugs and acetaminophen, and 16 the effects of adjuvant analgesics.ConclusionsSleep quality may be adversely affected by a variety of medications used in clinical practice, including those used in analgesic indications. The class of analgesics most affecting sleep quality are opioids.Copyright © 2022 American Society for Pain Management Nursing. Published by Elsevier Inc. All rights reserved.

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