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- John F Fahy, Eric W Emerling, and Lynne M Sterni.
- From the Department of Anesthesiology, Naval Medical Center San Diego, San Diego, California.
- A A Pract. 2022 Nov 1; 16 (11): e01637e01637.
AbstractA 13-year-old girl with a voltage-gated sodium channel mutation (SCN8A)-associated intractable epilepsy presented for bilateral mastectomy for painful juvenile fibroadenomatosis. Sodium channel mutations are more frequently diagnosed with continued advances in genetic testing. Understanding the effects of sodium channel mutations is important to provide safe anesthetic care to these patients. In this article, we discuss what is known regarding the physiology of SCN8A channels and the anesthetic considerations when caring for patients with an SCN8A mutation.Copyright © 2022 International Anesthesia Research Society.
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