• Gillis Greiwe, Moritz Flick, Alexander Hapfelmeier, Martin S Winkler, Rainer Nitzschke, Daniel Frings, and Bernd Saugel.
• From the Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (GG, MF, RN, BS), the Institute of General Practice and Health Services Research, School of Medicine, Technical University of Munich, Munich, Germany (AH), the Institute of AI and Informatics in Medicine, School of Medicine, Technical University of Munich, Munich, Germany (AH), the Department of Anesthesiology and Intensive Care, University Medical Center Göttingen, Göttingen, Germany (MSW), the Department of Intensive Care Medicine, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (DF), the Outcomes Research Consortium, Cleveland, Ohio, USA (BS).
• Eur J Anaesthesiol. 2023 Jun 1; 40 (6): 436441436-441.

BackgroundMeasuring cardiac output (CO) is important in patients treated with veno-venous extracorporeal membrane oxygenation (vvECMO) because vvECMO flow and CO need to be balanced. Uncalibrated pulse wave analysis with the Pressure Recording Analytical Method (PRAM) may be suitable to measure CO in patients with vvECMO therapy.ObjectiveTo assess the agreement between CO measured by PRAM (PRAM-CO; test method) and CO measured by transthoracic echocardiography (TTE-CO; reference method).DesignA prospective observational method comparison study.SettingThe ICU of a German university hospital between March and December 2021.PatientsThirty one adult patients with respiratory failure requiring vvECMO therapy: 29 of the 31 patients (94%) were treated for COVID-19 related respiratory failure.Main Outcome MeasuresPRAM-CO and TTE-CO were measured simultaneously at two time points in each patient with at least 20 min between measurements. A radial or femoral arterial catheter-derived blood pressure waveform was used for PRAM-CO measurements. TTE-CO measurements were conducted using the pulsed wave Doppler-derived velocity time integral of the left ventricular outflow tract (LVOT) and the corresponding LVOT diameter. PRAM-CO and TTE-CO were compared using Bland-Altman analysis and the percentage error (PE). We defined a PE of <30% as clinically acceptable.ResultsMean ± SD PRAM-CO was 6.86 ± 1.49 l min -1 and mean TTE-CO was 6.94 ± 1.58 l min -1 . The mean of the differences between PRAM-CO and TTE-CO was 0.09 ± 0.73 l min -1 with a lower 95% limit of agreement of -1.34 l min -1 and an upper 95% limit of agreement of 1.51 l min -1 . The PE was 21%.ConclusionsThe agreement between PRAM-CO and TTE-CO is clinically acceptable in adult patients with vvECMO therapy.Copyright © 2023 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited.

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