• Internal medicine · Dec 2023

    Case Reports

    Lung Injury Induced by Crizotinib and Entrectinib in a Patient with ROS1-rearranged Non-small-cell Lung Cancer: A Case Report.

    • Yoshiki Nishiyama, Shota Omori, Hiroyuki Matsumoto, Kosaku Komiya, and Kazufumi Hiramatsu.
    • Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Japan.
    • Intern. Med. 2023 Dec 1; 62 (23): 350735103507-3510.

    AbstractWe herein report the first case of c-ros oncogene 1 (ROS1)-rearranged advanced non-small-cell lung cancer (NSCLC) in which lung injury was induced by crizotinib and entrectinib. Crizotinib was administered as first-line chemotherapy in a woman in her early 70s with stage IV NSCLC showing ROS1 rearrangement. This resulted in the development of drug-induced organizing pneumonia, which was alleviated by discontinuing drug administration and giving corticosteroids. Following second-line chemotherapy with entrectinib, a similar lung injury was noted. In cases of crizotinib-induced lung injury, physicians must be alert for drug-induced lung injury in subsequent treatment with entrectinib.

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