• Internal medicine · Dec 2023

    Case Reports

    Gastric Flat Elevated Undifferentiated Signet-ring Cell Mucosal Cancer Lesion Detected in a Case Without Helicobacter pylori Infection.

    • Kanako Kishi, Kyoichi Adachi, Utae Sakamoto, Takafumi Yuki, Yoshinori Kushiyama, Hiroshi Miura, Eiko Okimoto, Norihisa Ishimura, and Shunji Ishihara.
    • Health Center, Shimane Environment and Health Public Corporation, Japan.
    • Intern. Med. 2023 Dec 1; 62 (23): 346934723469-3472.

    AbstractProtruded signet-ring cell carcinoma (SRCC) is extremely rare. We herein report a rare case of flat elevated gastric SRCC in a patient without Helicobacter pylori infection. Esophagogastroduodenoscopy of a woman in her 50s revealed a flat, whitish lesion in the gastric body with elevation. Histological results of an endoscopically biopsied specimen led to a diagnosis of SRCC. Resection using endoscopic submucosal dissection was performed, and histology results revealed that the tumor was localized in the lamina propria. The size was 10×6 mm, and a protrusion had been formed by SRCC enlargement without destruction of the surface epithelium structure.

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