• Internal medicine · Dec 2023

    Review Case Reports

    Pulmonary Hypertension Associated with Anti-synthetase Syndrome: A Case Report and Literature Review.

    • Yutaro Yoshitomi, Yuichi Suwa, Haruka Tsuchiya, Manaka Goto, Bunki Natsumoto, Hirofumi Shoda, and Keishi Fujio.
    • Department of Allergy and Rheumatology, The University of Tokyo Hospital, Japan.
    • Intern. Med. 2023 Dec 15; 62 (24): 368536893685-3689.

    AbstractPulmonary hypertension (PH) is a serious condition in which there is an abnormally high pressure in the pulmonary arteries that can occur as a complication of connective tissue diseases. Although the relationship between PH and systemic lupus erythematosus or systemic sclerosis has been well-characterized, PH rarely occurs in patients with anti-synthetase syndrome (ASS), and little is known about the pathophysiology and clinical outcome of patients with ASS-PH. We herein report a patient with anti-Jo-1-positive ASS complicated by PH and discuss the treatment strategy through a review of previously reported cases.

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