• Internal medicine · Dec 2023

    Case Reports

    Cholangiocarcinoma Resembling IgG4-related Sclerosing Cholangitis.

    • Kazuaki Akahoshi, Atsushi Kanno, Tetsurou Miwata, Hiroki Nagai, Kensuke Yokoyama, Eriko Ikeda, Kozue Ando, Kiichi Tamada, Noriyoshi Fukushima, Alan Kawarai Lefor, and Hironori Yamamoto.
    • Department of Medicine, Division of Gastroenterology, Jichi Medical University, Japan.
    • Intern. Med. 2023 Dec 1; 62 (23): 349535003495-3500.

    AbstractA 66-year-old man diagnosed with immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) with diffuse intrahepatic bile duct stenosis and elevated serum IgG4 levels was referred for a further examination because of elevated serum carbohydrate antigen 19-9 levels despite treatment with corticosteroids. An umbilical nodule was found on a physical examination and a biopsy showed adenocarcinoma. Although several imaging studies revealed no changes from prior studies, bile cytology collected by endoscopic retrograde cholangiopancreatography showed adenocarcinoma. Consequently, the patient was diagnosed with cholangiocarcinoma resembling IgG4-SC after detecting an umbilical metastasis, also known as Sister Mary Joseph's nodule.

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