• J. Cardiothorac. Vasc. Anesth. · Sep 2023

    Randomized Controlled Trial

    Association Between Postoperative Delirium and Long-Term Subjective Cognitive Decline in Older Patients Undergoing Cardiac Surgery: A Secondary Analysis of the Minimizing Intensive Care Unit Neurological Dysfunction with Dexmedetomidine-Induced Sleep Trial.

    • Grace E Namirembe, Sarah Baker, Marissa Albanese, Ariel Mueller, Jason Z Qu, Jennifer Mekonnen, Kwame Wiredu, M Brandon Westover, Timothy T Houle, Oluwaseun Akeju, and Minimizing Intensive Care Unit Neurological Dysfunction with Dexmedetomidine-Induced Sleep Study Team.
    • Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
    • J. Cardiothorac. Vasc. Anesth. 2023 Sep 1; 37 (9): 170017061700-1706.

    ObjectivesThis study aimed to evaluate whether a measure of subjective cognitive decline (SCD), the Patient-Reported Outcomes Measurement Information System (PROMIS) Applied Cognition-Abilities questionnaire, was associated with postoperative delirium. It was hypothesized that delirium during the surgical hospitalization would be associated with a decrease in subjective cognition up to 6 months after cardiac surgery.DesignThis was a secondary analysis of data from the Minimizing Intensive Care Unit Neurological Dysfunction with Dexmedetomidine-induced Sleep randomized, placebo-controlled, parallel-arm superiority trial.SettingData from patients recruited between March 2017 and February 2022 at a tertiary medical center in Boston, Massachusetts were analyzed in February 2023.ParticipantsData from 337 patients aged 60 years or older who underwent cardiac surgery with cardiopulmonary bypass were included.InterventionsPatients were assessed preoperatively and postoperatively at 30, 90, and 180 days using the subjective PROMIS Applied Cognition-Abilities and telephonic Montreal Cognitive Assessment.Measurement And Main ResultsPostoperative delirium occurred within 3 days in 39 participants (11.6%). After adjusting for baseline function, participants who developed postoperative delirium self-reported worse cognitive function (mean difference [MD] -2.64 [95% CI -5.25, -0.04]; p = 0.047) up to 180 days after surgery, as compared with nondelirious patients. This finding was consistent with those obtained from objective t-MoCA assessments (MD -0.77 [95% CI -1.49, -0.04]; p = 0.04).ConclusionsIn this cohort of older patients undergoing cardiac surgery, in-hospital delirium was associated with SCD up to 180 days after surgery. This finding suggested that measures of SCD may enable population-level insights into the burden of cognitive decline associated with postoperative delirium.Copyright © 2023 Elsevier Inc. All rights reserved.

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