• Nevo Barel, Tali Bdolach-Abraham, Philip Levin, and Sharon Einav.
• Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. Electronic address: nevo.barel@mail.huji.ac.il.
• J Crit Care. 2023 Oct 1; 77: 154331154331.

PurposeTo describe the characteristics, treatment and outcome, in particular weaning from mechanical ventilation (MV), of critically ill Patients with prior psychiatric conditions (PPC).MethodsSingle center, 6-year, retrospective study comparing critically ill PPC to randomly sex and age matched cohort without PPC (1:1 ratio). Main outcome measure- adjusted mortality rates. Secondary outcome measures- unadjusted mortality, rates of MV, extubation failure and amount/dose of pre-extubation sedatives/analgesics.ResultsIncluded were 214 patients per group. PPC adjusted mortality rates were higher in the ICU (14.0% vs 4.7%; OR 3.058 [95%CI 1.380, 6.774]; p = 0.006) and in-hospital (26.6% vs 13.1%; OR 2.639 [95% CI 1.496, 4.655]; p = 0.001). PPC had higher MV rates (63.6% vs 51.4%; p = 0.011). These patients were more likely to have more than two weaning attempts (29.4% vs 10.9%; p < 0.001), more commonly treated with >2 sedative drugs in the 48-h pre-extubation (39.2% vs 23.3%; p = 0.026) and received more propofol in the 24-h pre-extubation. PPC were more likely to self-extubate (9.6% vs 0.9%; p = 0.004) and had lower likelihood of success in planned extubations (50.0% vs 76.4%; p < 0.001).ConclusionCritically ill PPC had higher mortality rates than their matched counterparts. They also had higher MV rates and were more difficult to wean.Copyright © 2023 Elsevier Inc. All rights reserved.

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