• Thaís Lorenna Souza Sales, Maíra Viana Rego Souza-Silva, Polianna Delfino-Pereira, João Victor Baroni Neves, Manuela Furtado Sacioto, Vivian Costa Morais de Assis, Helena Duani, OliveiraNeimy Ramos deNRHospital Eduardo de Menezes, Belo Horizonte, MG, Brazil., Natália da Cunha Severino Sampaio, Lucas Emanuel Ferreira Ramos, Alexandre Vargas Schwarzbold, Alzira de Oliveira Jorge, Ana Luiza Bahia Alves Scotton, CastroBruno Mateus deBMHospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., SilvaCarla Thais Cândida Alves daCTCADHospital Santo Antônio, Curvelo, MG, Brazil., Carolina Marques Ramos, Fernando Anschau, Fernando Antonio Botoni, Genna Maira Santos Grizende, Guilherme Fagundes Nascimento, Karen Brasil Ruschel, Luanna Silva Monteiro Menezes, CastroLuís César deLCHospital Bruno Born, Lajeado, RS, Brazil., Luiz Antônio Nasi, Marcelo Carneiro, GodoyMariana Frizzo deMFHospital São Lucas PUCRS, Porto Alegre, RS, Brazil., Matheus Carvalho Alves Nogueira, Milton Henriques Guimarães Júnior, Patricia Klarmann Ziegelmann, Rafaela Charão de Almeida, Saionara Cristina Francisco, Sidney Teodoro Silveira Neto, Silvia Ferreira Araújo, Thiago Junqueira Avelino-Silva, Márlon Juliano Romero Aliberti, Magda Carvalho Pires, Eduardo Sérgio da Silva, and Milena Soriano Marcolino.
• Universidade Federal de São João del-Rei, Campus Centro Oeste Dona Lindu, Divinópolis, MG, Brazil; Instituto de Avaliação de Tecnologia em Saúde (IATS), Porto Alegre, RS, Brazil. Electronic address: thaislorennass30@yahoo.com.br.
• Clinics (Sao Paulo). 2023 Jan 1; 78: 100223100223.

ObjectiveTo evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection.MethodsThis is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables.ResultsThroughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999).ConclusionsOur results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group.Copyright © 2023 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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