• J Fam Pract · Jun 2023

    Meta Analysis

    Is there benefit to adding ezetimibe to a statin for the secondary prevention of CVD?

    • Vinay Reddy, James Allison, and Anne Mounsey.
    • Department of Family Medicine, University of North Carolina, Chapel Hill.
    • J Fam Pract. 2023 Jun 1; 72 (5): 227229227-229.

    AbstractYES. In patients with known cardiovascular disease (CVD), ezetimibe with a statin decreases major adverse cardiovascular events (MACE) but has no effect on all-cause and cardiovascular mortality, compared to a statin alone (strength of recommendation [SOR], A; meta-analysis of randomized controlled trials [RCTs] including 1 large RCT). In adults with atherosclerotic CVD (ASCVD), the combination of ezetimibe and a moderate-intensity statin (rosuvastatin 10 mg) was noninferior at decreasing cardiovascular death, major cardiovascular events, and nonfatal stroke, but was more tolerable, compared to a high-intensity statin (rosuvastatin 20 mg) alone (SOR, B; 1 RCT).

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