• David Chao-Chia Lu, Chadwick Boulay, ChanAdrian D CADCThe Ottawa Hospital Research Institute, Ottawa, ON, Canada., and Adam J Sachs.
• The Ottawa Hospital Research Institute, Ottawa, ON, Canada. Electronic address: dave6892@gmail.com.
• Neuromodulation. 2024 Apr 1; 27 (3): 409421409-421.

ObjectiveThis systematic review is conducted to identify, compare, and analyze neurophysiological feature selection, extraction, and classification to provide a comprehensive reference on neurophysiology-based subthalamic nucleus (STN) localization.Materials And MethodsThe review was carried out using the methods and guidelines of the Kitchenham systematic review and provides an in-depth analysis on methods proposed on STN localization discussed in the literature between 2000 and 2021. Three research questions were formulated, and 115 publications were identified to answer the questions.ResultsThe three research questions formulated are answered using the literature found on the respective topics. This review discussed the technologies used in past research, and the performance of the state-of-the-art techniques is also reviewed.ConclusionThis systematic review provides a comprehensive reference on neurophysiology-based STN localization by reviewing the research questions other new researchers may also have.Copyright © 2023 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.

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