• Turk J Med Sci · Jun 2023

    Real-life outcomes for oral disease-modifying treatments of relapsing-remitting multiple sclerosis patients: Adherence and adverse event profiles from Marmara University.

    • İrfan Şencan, Oğuz Karabay, Fatma Aybala Altay, Serap Süzük Yıldız, Hüsniye Şimşek, Melih Gaffar Gözükara, Semanur Kuzi, Gülden Eser Karlıdağ, Şafak Kaya, Gülnur Kul, Emine Türkoğlu, Büşra Ergüt Sezer, Nesibe Korkmaz, Sibel Yıldız Kaya, Merve Sefa Sayar, Dilek Bulut, Fethiye Akgül, Yasemin Çağ, Canan Ağalar, DursunZehra BeştepeZBDepartment of Infectious Diseases and Clinical Microbiology, Kayseri Medicine Faculty, University of Health Sciences, Kayseri, Turkey., Meltem Taşbakan, Sabire Şöhret Aydemir, Derya Seyman, Mustafa Yıldırım, Zafer Habip, Nilgün Altın, Hanife Uzar, Begüm Bektaş, EnginDerya ÖztürkDÖDepartment of Infectious Diseases and Clinical Microbiology, Sancaktepe İlhan Varank Training and Research Hospital, Republic of Turkey Ministry of Health, İstanbul, Turkey., ErdemHüseyin AytaçHADepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, İzmir, Turkey., and Serkan Sürme.
    • Department of Infectious Diseases and Clinical Microbiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
    • Turk J Med Sci. 2023 Jun 1; 53 (3): 780790780-790.

    BackgroundTo have country-wide information about multidrug resistance (MDR) in isolates from community-acquired urinary tract infections (CAUTI) of Turkey, in terms of resistance rates and useful options.MethodsWe used a geocode standard, nomenclature of territorial units for statistics (NUTS), and a total of 1588 community-acquired isolates of 20 centres from 12 different NUTS regions between March 2019 and March 2020 were analysed.ResultsOf the 1588 culture growths, 1269 (79. 9%) were Escherichia coli and 152 (9.6%) were Klebsiella spp. Male sex, advancedage, and having two or more risk factors showed a statistically significant relation with MDR existence (p < 0.001, p: 0.014, p < 0.001, respectively) that increasing number of risk factors or degree of advancing in age directly affects the number of antibiotic groups detected to have resistance by pathogens. In total, MDR isolates corresponded to 36.1% of our CAUTI samples; MDR existence was 35.7% in E. coli isolates and 57.2% in Klebsiella spp. isolates. Our results did not show an association between resistance or MDR occurrence rates and NUTS regions.DiscussionThe necessity of urine culture in outpatient clinics should be taken into consideration, at least after evaluating risk factorsfor antibacterial resistance individually. Community-acquired UTIs should be followed up time- and region-dependently. Antibiotic stewardship programmes should be more widely and effectively administrated.

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