• Lancet neurology · Nov 2006

    Comparative Study

    Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study.

    • Alexis Elbaz, Lorene M Nelson, Haydeh Payami, John P A Ioannidis, Brian K Fiske, Grazia Annesi, Carmine BelinAndreaA, Stewart A Factor, Carlo Ferrarese, Georgios M Hadjigeorgiou, Donald S Higgins, Hideshi Kawakami, Rejko Krüger, Karen S Marder, Richard P Mayeux, George D Mellick, John G Nutt, Beate Ritz, Ali Samii, Caroline M Tanner, Christine Van Broeckhoven, Stephen K Van Den Eeden, Karin Wirdefeldt, Cyrus P Zabetian, Marie Dehem, Jennifer S Montimurro, Audrey Southwick, Richard M Myers, and Thomas A Trikalinos.
    • INSERM, Unit 708, Paris, France.
    • Lancet Neurol. 2006 Nov 1; 5 (11): 917923917-23.

    BackgroundA genome-wide association study identified 13 single-nucleotide polymorphisms (SNPs) significantly associated with Parkinson's disease. Small-scale replication studies were largely non-confirmatory, but a meta-analysis that included data from the original study could not exclude all SNP associations, leaving relevance of several markers uncertain.MethodsInvestigators from three Michael J Fox Foundation for Parkinson's Research-funded genetics consortia-comprising 14 teams-contributed DNA samples from 5526 patients with Parkinson's disease and 6682 controls, which were genotyped for the 13 SNPs. Most (88%) participants were of white, non-Hispanic descent. We assessed log-additive genetic effects using fixed and random effects models stratified by team and ethnic origin, and tested for heterogeneity across strata. A meta-analysis was undertaken that incorporated data from the original genome-wide study as well as subsequent replication studies.FindingsIn fixed and random-effects models no associations with any of the 13 SNPs were identified (odds ratios 0.89 to 1.09). Heterogeneity between studies and between ethnic groups was low for all SNPs. Subgroup analyses by age at study entry, ethnic origin, sex, and family history did not show any consistent associations. In our meta-analysis, no SNP showed significant association (summary odds ratios 0.95 to 1.08); there was little heterogeneity except for SNP rs7520966.InterpretationOur results do not lend support to the finding that the 13 SNPs reported in the original genome-wide association study are genetic susceptibility factors for Parkinson's disease.

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