• Hamid Salehi Mishani, Alireza Jalalizand, and Mehrdad Modaresi.
• Department of Plant Protection, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
• J Res Med Sci. 2023 Jan 1; 28: 5252.

BackgroundAcross the world, people are exposed to pesticide residues in agricultural products. Various materials are used to deal with effects of these residues. Considering the wide use of dichlorvos and acetamiprid in crops, pesticide residues in cucumber and its effects on the biochemical parameters of mice were calculated, and the protective role of donkey colostrum (DC) to deal with the pesticide effects was investigated.Materials And MethodsDichlorvos (4 ml/l) and acetamiprid (0.5 g/l) residues, after spraying cucumber plants, were 0.5 and 1.5 mg/kg, respectively. For 60 days, the mentioned doses were used in the drinking water of 4 groups of mice. No substances were added to mice drinking water in the control group while dichlorvos and acetamiprid groups received 0.5 and 1.5 mg/kg of pesticide, respectively, and the mixed group received a combination of two pesticides. In order to investigate the protective role of DC, 0.2 ml of colostrum was given to each of the groups in a similar division and timing.ResultsIn the biochemical sector, albumin (control 2.96, dichlorvos 1.86, acetamiprid 2.00, and mix 1.6 g/dl) and total protein levels reduced. Alanine aminotransferase (control 41.8, dichlorvos 56.2, acetamiprid 58.4, and mix 68 iu/l) and aspartate aminotransferase levels increased. In the protective role of colostrum, albumin (control 2.96, dichlorvos 2.74, acetamiprid 2.80, and mix 2.50 g/dl) and alanine aminotransferase changes (control 41.8, dichlorvos 43.4, acetamiprid 46.0, and mix 52.2 iu/l) were recorded (P = 0.0001).ConclusionAdding pesticides to mice drinking water causes liver disorders and DC can be effective in protecting these damages.Copyright: © 2023 Journal of Research in Medical Sciences.

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