• Lynn McNicoll, Margaret A Pisani, E Wesley Ely, David Gifford, and Sharon K Inouye.
• Department of Internal Medicine, School of Medicine, Brown University, Providence, Rhode Island, USA. Lynn_McNicoll@brown.edu
• J Am Geriatr Soc. 2005 Mar 1;53(3):495-500.

ObjectivesTo compare the Confusion Assessment Method (CAM) and CAM for the Intensive Care Unit (CAM-ICU) methods for detecting delirium in alert, nonintubated older ICU patients.DesignComparison study.SettingFourteen-bed medical ICU of an 800-bed university teaching hospital.ParticipantsTwenty-two patients aged 65 and older admitted to the ICU.MeasurementsTwo blinded, trained clinician-researchers who had undergone interrater reliability testing interviewed patients separately, usually within 10 minutes of each other (up to 120 minutes). Each researcher examined patients for the four key CAM criteria: acuteness, inattention, disorganized thinking, and altered level of consciousness. One researcher used the CAM method with the Mini-Mental State Examination and Digit Span; the other researcher used the CAM-ICU method with nonverbal cognitive and attention tasks.ResultsRates of delirium were 68% according to CAM and 50% according CAM-ICU. Comparing the two methods, agreement was 82%, with a kappa of 0.64. Using the CAM as the reference standard, the CAM-ICU had a sensitivity of 73% (95% confidence interval (CI)=60-86) and specificity of 100% (95% CI=56-100). There were four false-negative ratings using the CAM-ICU. Reasons for disparate results were that the CAM used more-detailed cognitive testing that detected more deficits (3 patients) and the time elapsed (90 minutes) between ratings in one patient with markedly fluctuating symptoms.ConclusionCAM and CAM-ICU agreement was moderately high. Although the CAM-ICU is recommended for ICU patients because of its brevity and ease of use, the standard CAM method may detect more subtle cases of delirium in nonintubated, verbal ICU patients.

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