• Internal medicine · May 2024

    Case Reports

    Clinical Utility of Flow Cytometry for Detection of Anti-Jkb IgM in Acute Haemolytic Transfusion Reaction: A Case Report.

    • Keiki Nagaharu, Takuya Izumi, Mitsuko Maruyama, Yuka Sugimoto, Kohshi Ohishi, Isao Tawara, Eiji Usui, and Shigehisa Tamaki.
    • Department of Hematology, Mie University Hospital, Japan.
    • Intern. Med. 2024 May 1; 63 (9): 127312751273-1275.

    AbstractAcute hemolytic transfusion reaction (AHTR) is a rare but life-threatening complication of transfusion. We herein report a case of anti-Jkb IgM-related AHTR. Two hours after an 80-year-old man with myelodysplastic syndrome received a packed red blood cell (RBC) A+/Rh-/Jkb+/c- transfusion, he developed acute respiratory failure and a fever. Although he had tested negative in routine screening tests, the 37°C normal saline test was weakly positive for Jkb. We confirmed the presence of anti-Jkb IgM in the patient's serum by flow cytometry. This case demonstrates the potential utility of flow cytometry for IgM detection.

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