• Mark Ebden, Lior M Elkaim, Sara Breitbart, Han Yan, Nebras Warsi, MyLoi Huynh, Karim Mithani, Venetucci GouveiaFlaviaFNeurosciences and Mental Health Program, the Hospital for Sick Children, Toronto, Ontario, Canada., Alfonso Fasano, George M Ibrahim, and Carolina Gorodetsky.
• Neurosciences and Mental Health Program, the Hospital for Sick Children, Toronto, Ontario, Canada.
• Neuromodulation. 2024 Apr 1; 27 (3): 551556551-556.

BackgroundNovel deep brain stimulation devices can record local field potentials (LFPs), which represent the synchronous synaptic activity of neuronal populations. The clinical relevance of LFPs in patients with dystonia remains unclear.ObjectivesWe sought to determine whether chronic LFPs recorded from the globus pallidus internus (GPi) were associated with symptoms of dystonia in children.Materials And MethodsTen patients with heterogeneous forms of dystonia (genetic and acquired) were implanted with neurostimulators that recorded LFP spectral snapshots. Spectra were compared across parent-reported asymptomatic and symptomatic periods, with daily narrowband data superimposed in 24 one-hour bins.ResultsSpectral power increased during periods of registered dystonic symptoms: mean increase = 102%, CI: (76.7, 132). Circadian rhythms within the LFP narrowband time series correlated with dystonic symptoms: for delta/theta-waves, correlation = 0.33, CI: (0.18, 0.47) and for alpha waves, correlation = 0.27, CI: (0.14, 0.40).ConclusionsLFP spectra recorded in the GPi indicate a circadian pattern and are associated with the manifestation of dystonic symptoms.Copyright © 2023 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.

15 keywords...

hide…