• Annals of surgery · Mar 2024

    Long-term Outcomes of Robot-assisted versus Laparoscopic Surgery for Colon Cancer: A Nationwide Register-based Cohort Study.

    • Pedja Cuk, Lasse Kaalby, Ulrik Deding, Issam Al-Najami, and Mark Bremholm Ellebæk.
    • Department of General and Colorectal Surgery, Aabenraa, University Hospital of Southern Denmark, Odense, Denmark.
    • Ann. Surg. 2024 Mar 1; 279 (3): 456461456-461.

    ObjectiveTo determine long-term survival in patients undergoing robot-assisted surgery (RAS) or laparoscopic surgery (LAS) for colon cancer.BackgroundThe potential long-term benefits of RAS compared with LAS for colon cancer are not well examined. Using a register-based approach, we aimed to compare these 2 surgical platforms in an analysis of long-term outcomes, including recurrence-free survival and all-cause- and colon cancer-specific mortality.MethodsA nationwide register-based cohort study of patients with Union for International Cancer Control stage I-III colon cancer undergoing planned RAS or LAS from 2010 through 2018. Patient demographic, clinical, and pathological data were retrieved from Danish national registers. Survival and recurrence rates were estimated by Cox proportional hazard multivariate regression analysis adjusting for baseline covariates.ResultsA total of 7565 patients [LAS=6905 (91%) and RAS=660 (9%)] were included in the complete case survival analysis. Patients undergoing LAS had a significantly increased risk of cancer recurrence [LAS=1178 (17.1%), RAS=82 (12.4%), P =0.002] with a mean follow-up time of 4.93 years (standard deviation 2.47). The survival analysis of recurrence-free survival favored RAS [hazard ratio adjusted =0.80, 95% CI (0.64-1.00), P =0.049]. No associations between the 2 surgical platforms were evident regarding all-cause [hazard ratio adjusted =0.98, 95% CI (0.82-1.17), P =0.783] or colon cancer-specific mortality [hazard ratio adjusted =0.89, 95% CI (0.67-1.18), P =0.405].ConclusionsAdopting RAS for colon cancer was associated with improved recurrence-free survival. However, it did not cause a lower all-cause- or colon cancer-specific mortality.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

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