• Michael R Kolber, Scott Klarenbach, Michel Cauchon, Mike Cotterill, Loren Regier, Raelene D Marceau, Norah Duggan, Rebecca Whitley, Alex S Halme, Tanis Poshtar, G Michael Allan, Christina S Korownyk, Joey Ton, Liesbeth Froentjes, Samantha S Moe, Danielle Perry, Betsy S Thomas, James P McCormack, Jamie Falk, Nicolas Dugré, Scott R Garrison, Jessica E M Kirkwood, Jennifer Young, Émélie Braschi, Allison Paige, Jen Potter, Justin Weresch, and Adrienne J Lindblad.
• Professor in the Department of Family Medicine at the University of Alberta in Edmonton.
• Can Fam Physician. 2023 Oct 1; 69 (10): 675686675-686.

ObjectiveTo update the 2015 clinical practice guideline and provide a simplified approach to lipid management in the prevention of cardiovascular disease (CVD) for primary care.MethodsFollowing the Institute of Medicine's Clinical Practice Guidelines We Can Trust, a multidisciplinary, pan-Canadian guideline panel was formed. This panel was represented by primary care providers, free from conflicts of interest with industry, and included the patient perspective. A separate scientific evidence team performed evidence reviews on statins, ezetimibe, proprotein convertase subtilisin-kexin type 9 inhibitors, fibrates, bile acid sequestrants, niacin, and omega-3 supplements (docosahexaenoic acid with eicosapentaenoic acid [EPA] or EPA ethyl ester alone [icosapent]), as well as on 11 supplemental questions. Recommendations were finalized by the guideline panel through use of the Grading of Recommendations Assessment, Development and Evaluation methodology.RecommendationsAll recommendations are presented in a patient-centred manner designed with the needs of family physicians and other primary care providers in mind. Many recommendations are similar to those published in 2015. Statins remain first-line therapy for both primary and secondary CVD prevention, and the Mediterranean diet and physical activity are recommended to reduce cardiovascular risk (primary and secondary prevention). The guideline panel recommended against using lipoprotein a, apolipoprotein B, or coronary artery calcium levels when assessing cardiovascular risk, and recommended against targeting specific lipid levels. The team also reviewed new evidence pertaining to omega-3 fatty acids (including EPA ethyl ester [icosapent]) and proprotein convertase subtilisin-kexin type 9 inhibitors, and outlined when to engage in informed shared decision making with patients on interventions to lower cardiovascular risk.ConclusionThese updated evidence-based guidelines provide a simplified approach to lipid management for the prevention and management of CVD. These guidelines were created by and for primary health care professionals and their patients.Copyright © 2023 the College of Family Physicians of Canada.

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