• AiJun Peng, LiBing Zhang, Hai Zhao, and LiangXue Zhou.
• Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan province.
• Medicine (Baltimore). 2019 Nov 1; 98 (47): e17888e17888.

RationaleHemangiopericytoma (HPC) is a rare pediatric neoplasm with a high risk of bleeding, aggressive growth and high early relapse rates. Surgical excision remains the mainstream treatment, while the functions of chemotherapy and radiotherapy remain controversial. In particular, an infantile giant extracranial HPC located in the forehead has never been reported.Patient ConcernsA 3-day-old girl was delivered normally with a giant tumor localized mainly in the right frontal region. The surface of the mass was filled with vascularity.DiagnosisAccording to the results of imaging and pathological examinations, the diagnosis was HPC grade II.InterventionsGross total resection of the tumor and the invading partial frontal bone followed by skin scalp reconstruction was carried out without any blood transfusion.OutcomesNo recurrence was identified during 5 years of follow-up. And better outcomes can be achieved without adjuvant therapy.LessonsMultimodality imaging and a collaborative multidisciplinary approach are indispensable for the successful surgical management of infantile HPC, especially for giant tumors and their potential risk of life-threatening bleeding. Gross total resection is the optimal option for infantile HPC, and even without adjuvant therapy, it achieves better outcomes.

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