• Zheng Zhou.
• Department of Gastroenterology, The People's Hospital of Xuancheng City, Anhui Province, China.
• Medicine (Baltimore). 2023 Oct 27; 102 (43): e35372e35372.

RationaleTo analyze the effect of streptomyces protease combined with dyclonine in painless magnifying endoscopy.Patient ConcernsA total of 100 patients who underwent magnification endoscopy in our hospital from January 2021 to June 2022 were retrospectively analyzed.DiagnosesThe diagnoses were made by painless magnifying endoscopy and narrow-band imaging combined with pathological findings.InterventionsThe patients were divided into the observation group and control group, the observation group was streptomyces protease combined with dyclonine group, and the control group was dyclonine group, 50 cases in each group. The visibility score under gastroscopy was compared between the 2 groups, and the morphological classification of gastric pit and collecting veins was observed. The detection rates of small lesions and early cancer were compared between the 2 groups. The examination time and adverse reactions were compared between the 2 groups.OutcomesCompared with the control group, the streptomyces protease combined with dyclonine group had better clear visibility and a higher detection rate of small lesions, but there was no significant difference in early cancer detection rate between the 2 groups. The examination time of streptomyces protease combined with dyclonine group was relatively prolonged, but there was no significant difference in the incidence of adverse reactions between the 2 groups.LessonsStreptomyces protease combined with dyclonine plays a certain role in painless magnifying gastroscopy, which can improve the visibility of gastroscopy, improve the detection rate of small lesions, help to find gastric dysplasia and early gastric cancer diagnosis, and does not increase the incidence of adverse reactions.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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