• Alexandra M Zaborowski, Katie Doogan, Siobhan Clifford, Gavin Dowling, Farah Kazi, Karina Delaney, Himanshu Yadav, Aaron Brady, James Geraghty, Denis Evoy, Jane Rothwell, Damian McCartan, Anna Heeney, Mitchel Barry, Siun M Walsh, Maurice Stokes, Malcolm R Kell, Michael Allen, Colm Power, HillArnold D KADKDepartment of Breast Surgery, Beaumont Hospital, Dublin, Ireland., Elizabeth Connolly, Dhafir Alazawi, Terence Boyle, Mark Corrigan, Peter O'Leary, and Ruth S Prichard.
• Department of Breast Surgery, St Vincent's University Hospital, Dublin, Ireland.
• Br J Surg. 2024 Jan 3; 111 (1).

BackgroundThe necessity of performing a sentinel lymph node biopsy in patients with clinically and radiologically node-negative breast cancer after neoadjuvant chemotherapy has been questioned. The aim of this study was to determine the rate of nodal positivity in these patients and to identify clinicopathological features associated with lymph node metastasis after neoadjuvant chemotherapy (ypN+).MethodsA retrospective multicentre study was performed. Patients with cT1-3 cN0 breast cancer who underwent sentinel lymph node biopsy after neoadjuvant chemotherapy between 2016 and 2021 were included. Negative nodal status was defined as the absence of palpable lymph nodes, and the absence of suspicious nodes on axillary ultrasonography, or the absence of tumour cells on axillary nodal fine needle aspiration or core biopsy.ResultsA total of 371 patients were analysed. Overall, 47 patients (12.7%) had a positive sentinel lymph node biopsy. Nodal positivity was identified in 22 patients (29.0%) with hormone receptor+/human epidermal growth factor receptor 2- tumours, 12 patients (13.8%) with hormone receptor+/human epidermal growth factor receptor 2+ tumours, 3 patients (5.6%) with hormone receptor-/human epidermal growth factor receptor 2+ tumours, and 10 patients (6.5%) with triple-negative breast cancer. Multivariable logistic regression analysis showed that multicentric disease was associated with a higher likelihood of ypN+ (OR 2.66, 95% c.i. 1.18 to 6.01; P = 0.018), whilst a radiological complete response in the breast was associated with a reduced likelihood of ypN+ (OR 0.10, 95% c.i. 0.02 to 0.42; P = 0.002), regardless of molecular subtype. Only 3% of patients who had a radiological complete response in the breast were ypN+. The majority of patients (85%) with a positive sentinel node proceeded to axillary lymph node dissection and 93% had N1 disease.ConclusionThe rate of sentinel lymph node positivity in patients who achieve a radiological complete response in the breast is exceptionally low for all molecular subtypes.© The Author(s) 2023. Published by Oxford University Press on behalf of BJS Society Ltd.

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