• Adarsh Aratikatla, Nicola Maffulli, Manu Gupta, Ishana A Potti, Anish G Potty, and Ashim Gupta.
• The Royal College of Surgeons in Ireland, Dublin D02 YN77, Ireland.
• Br. Med. Bull. 2024 Mar 13; 149 (1): 133113-31.

IntroductionThe existing treatment modalities for knee osteoarthritis (OA) do not actually address the pathology. Biological therapies, including those using material derived from perinatal tissues, represent a ground-breaking approach to alleviating the symptoms of OA of the knee.Source Of DataCurrent scientific literature published in PubMed (MEDLINE), Embase and Scopus databases. Trials registered in various clinical trial databases.Areas Of AgreementPerinatal tissues including Wharton's jelly (WJ) and associated mesenchymal stem cells (MSCs) can be used for the management of knee OA.Areas Of ControversyThe efficacy of WJ and associated MSCs in the management of knee OA is still controversial.Growing PointsThe use of WJ and associated MSCs in the management of knee OA is safe and appears to be effective.Areas Timely For Developing ResearchThe present published evidence suggests that WJ tissue and associated MSCs offer an encouraging alternative for the management of knee OA. The published in vitro, preclinical and clinical investigations demonstrate the therapeutic potential of WJ and promote further research in this field to provide symptomatic relief to patients suffering from OA, aiming also to regenerate the osteoarthritic hyaline cartilage, with disease-modifying effects. Future adequately powered randomized controlled trials should be undertaken to establish whether WJ is helpful in the management of OA of the knee.© The Author(s) 2023. Published by Oxford University Press.

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