• L Imeen van der Wal, Chloe C A Grim, Michael R Del Prado, David J van Westerloo, Marcus J Schultz, HelmerhorstHendrik J FHJFDepartment of Intensive Care, Leiden University Medical Centre, Leiden, The Netherlands.Department of Anaesthesiology, Leiden University Medical Centre, Leiden, The Netherlands., Martine C de Vries, Evert de Jonge, and ICONIC Investigators.
• Department of Intensive Care, Leiden University Medical Centre, Leiden, The Netherlands.
• Crit. Care Med. 2024 May 1; 52 (5): 694703694-703.

ObjectivesDeferred consent enables research to be conducted in the ICU when patients are unable to provide consent themselves, and there is insufficient time to obtain consent from surrogates before commencing (trial) treatment. The aim of this study was to evaluate how former ICU patients reflect on their participation in a study with deferred consent and examine whether their opinions are influenced by the quality of life (QoL) following hospital discharge.DesignSurvey study by questionnaire.SettingEight ICUs in The Netherlands.PatientsFormer ICU patients who participated in the ICONIC trial, a multicenter randomized clinical trial that evaluated oxygenation targets in mechanically ventilated ICU patients.InterventionsParticipants enrolled in the ICONIC trial in one of the eight participating centers in The Netherlands received a questionnaire 6 months after randomization. The questionnaire included 12 close-ended questions on their opinion about the deferred consent procedure. QoL was measured using the EQ-5D-5L questionnaire. By calculating the EQ-5D index, patients were divided into four QoL quartiles, where Q1 reflects the lowest and Q4 is the highest.Measurements And Main ResultsOf 362 participants who were contacted, 197 responded (54%). More than half of the respondents (59%) were unaware of their participation in the ICONIC study. In total 61% were content with the deferred consent procedure, 1% were not content, 25% neutral, 9% did not know, and 9% answered "other." Those with a higher QoL were more likely to be content ( p = 0.02). In all QoL groups, the legal representative was the most often preferred individual to provide consent.ConclusionsFormer ICU patients who participated in the ICONIC study often did not remember their participation but were predominantly positive regarding the use of deferred consent. Those with a higher QoL were most likely to be content.Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and Wolters Kluwer Health, Inc.

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