• Int J Med Sci · Jan 2024

    Review

    NAD+-A Hub of Energy Metabolism in Heart Failure.

    • Yaoxin Wu, Zuowei Pei, and Peng Qu.
    • Faculty of Medicine, Dalian University of Technology, 116024, Dalian, China.
    • Int J Med Sci. 2024 Jan 1; 21 (2): 369375369-375.

    AbstractHeart failure is a condition where reduced levels of adenosine triphosphate (ATP) affect energy supply in myocardial cells. Nicotinamide adenine dinucleotide (NAD+) plays a crucial role as a coenzyme for electron transfer in energy metabolism. Decreased NAD+ levels in myocardial cells lead to inadequate ATP production and increased susceptibility to heart failure. Researchers are exploring ways to increase NAD+ levels to alleviate heart failure. Targets such as sirtuin2 (sirt2), sirtuin3 (sirt3), Poly (ADP-ribose) polymerase (PARP), and diastolic regulatory proteins are being investigated. NAD+ supplementation has shown promise, even in heart failure with preserved ejection fraction (HFpEF). By focusing on NAD+ as a central component of energy metabolism, it is possible to improve myocardial activity, heart function, and address energy deficiency in heart failure.© The author(s).

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