• Eyal Kleinhendler, Maya Rosman, Elisabeth Fireman, Ophir Freund, Ivgeny Gershman, Irena Pumin, Tal Perluk, Boaz Tiran, Avraham Unterman, and Amir Bar-Shai.
• Drs Kleinhendler, Freund, Gershman, Pumin, Perluk, Tiran, Unterman, and Bar-Shai are affiliated with Division of Pulmonary Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. Dr Rosman is affiliated with Department of Pulmonary Medicine, Walfson Medical Center and Sackler Faculty of Medicine, Holon, Israel. Dr Fireman is affiliated with Laboratory of Pulmonary Diseases, Laboratory National Service for ILD, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. eyalkl@tlvmc.gov.il.
• Respir Care. 2024 Mar 27; 69 (4): 415421415-421.

BackgroundImpulse oscillometry (IOS) is a noninvasive technique that measures lung physiology independently of patient effort. In the present study, we aimed to investigate the utility of IOS parameters in comparison with pulmonary function testing (PFT) among hospitalized subjects, with emphasis on obstructive and small airway diseases.MethodsSixty-one subjects hospitalized either with unexplained dyspnea or for pre-surgery evaluation were included in the study. All subjects underwent PFTs and IOS test. The correlation between IOS results and PFTs was examined in different subgroups. The ability of IOS parameters to predict abnormal PFTs was evaluated using the area under the receiver operating characteristic (ROC) curve, and optimal cutoff values were calculated.ResultsIOS results were found to correlate with PFT values. Subgroup analysis revealed that these correlations were higher in younger (age < 70) and non-obese (body mass index < 25kg/m2) subjects. The resonant frequency was an independent predictor and had the best predictive ability for abnormal FEV1/FVC (area under the ROC curve 0.732 [95% CI 0.57-0.90], optimal cutoff 17 Hz, 87% sensitivity, 62% specificity) and abnormal forced expiratory flow during the middle half of the FVC maneuver (area under the ROC curve 0.667 [95% CI 0.53-0.81], optimal cutoff 15 Hz, 77% sensitivity, 54% specificity). Area of reactance and the difference in respiratory resistance at 5 Hz and 20 Hz also showed a good predictive ability for abnormal FEV1/FVC (area under the ROC curve 0.716 and 0.730, respectively).ConclusionsWe found that the IOS performed well in diagnosing small airway and obstructive diseases among hospitalized subjects. IOS might serve as an alternative to standard PFTs in non-cooperative or dyspneic hospitalized patients.Copyright © 2024 by Daedalus Enterprises.

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