• Brian M Greenwood, Kalifa Bojang, Christopher J M Whitty, and Geoffrey A T Targett.
• Gates Malaria Partnership, Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1B 3DP, UK. brian.greenwood@lshtm.ac.uk
• Lancet. 2005 Apr 23; 365 (9469): 148714981487-98.

AbstractMalaria is the most important parasitic infection in people, accounting for more than 1 million deaths a year. Malaria has become a priority for the international health community and is now the focus of several new initiatives. Prevention and treatment of malaria could be greatly improved with existing methods if increased financial and labour resources were available. However, new approaches for prevention and treatment are needed. Several new drugs are under development, which are likely to be used in combinations to slow the spread of resistance, but the high cost of treatments would make sustainability difficult. Insecticide-treated bed-nets provide a simple but effective means of preventing malaria, especially with the development of longlasting nets in which insecticide is incorporated into the net fibres. One malaria vaccine, RTS,S/AS02, has shown promise in endemic areas and will shortly enter further trials. Other vaccines are being studied in clinical trials, but it will probably be at least 10 years before a malaria vaccine is ready for widespread use.

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