• Curr Pain Headache Rep · Apr 2024

    Review

    Trigeminal Postherpetic Neuralgia: From Pathophysiology to Treatment.

    • Christy S Niemeyer, Michael Harlander-Locke, Andrew N Bubak, Rachael Rzasa-Lynn, and Marius Birlea.
    • Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
    • Curr Pain Headache Rep. 2024 Apr 1; 28 (4): 295306295-306.

    Purpose Of ReviewTrigeminal postherpetic neuralgia (TG-PHN) is a neuropathic pain condition complicating herpes zoster (HZ) attributed to the trigeminal nerve. It poses significant challenges due to its persistent and debilitating nature. This review explores the clinical characteristics of TG-PHN, analyzes its pathophysiological underpinnings, and addresses existent and potential therapies.Recent FindingsTG-PHN is one of the most common and complex PHN locations. It has distinguishing clinical and pathophysiological characteristics, starting with viral triggered injuries to the trigeminal ganglion (TG) and peripheral tissue and involving the ascending and descending brain modulation pathways. Current therapies include vaccines, oral and topical medications, and interventional approaches, like nerve blocks and neurostimulation. This review covers TG-PHN's clinical and physiological components, treatment options, and potential future targets for improved management. By exploring the complexities of this condition, we aim to contribute to developing more effective and targeted therapies for patients suffering from trigeminal PHN.© 2024. The Author(s).

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