• Medicina clinica · May 2024

    Value of the tumor inhibitor of cellular immunity PDL-1 in the incidence of venous thrombosis in patients with gastric cancer.

    • Margarita Lorente and Kevin Doello.
    • Servicio de Oncología Médica, Hospital Virgen de las Nieves, Granada, Spain.
    • Med Clin (Barc). 2024 May 17; 162 (9): 425427425-427.

    IntroductionGastric cancer is one of the cancers most associated with thromboembolic phenomena. The objective of this article is to study if there is a correlation between thromboembolic phenomena in gastric cancer and tumor expression of PDL-1.MethodsTo this end, the association between thromboembolic events and PDL-1 expression was retrospectively studied in a sample of 46 patients from our hospital.ResultsThe results obtained revealed a statistically significant difference between the percentage of thromboembolic events between positive and negative PDL-1 with an increase in the latter with a P value of 0.034.ConclusionIn conclusion, the expression of PDL-1, and with it, of an inhibitory factor of the cellular immune response, correlates with a decrease in thromboembolic events in patients with gastric cancer, which could indicate the crucial role of the immune response in which thromboembolic events occur.Copyright © 2024 Elsevier España, S.L.U. All rights reserved.

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