• Pedja Cuk, Mindaugas Tiskus, Sören Möller, Kate Lykke Lambertsen, Backer MogensenChristianCInstitute of Regional Health Research, University of Southern Denmark, Odense, Denmark.Department of Emergency Medicine, Hospital Soenderjylland, University Hospital of Southern Denmark, Aabenraa, Denmark., Festersen NielsenMichaelMDepartment of General and Colorectal Surgery, University Hospital of Southern Jutland, Aabenraa, Denmark.Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Per Helligsø, Ismail Gögenur, and Bremholm EllebækMarkMOpen Patient Data Explorative Network, Odense University Hospital, Odense, Denmark.Department of Clinical Research, University of Southern Denmark, Odense, Denmark.Research Unit of Surgery, Odense University Hospital, Odense, Denmark..
• Department of General and Colorectal Surgery, University Hospital of Southern Jutland, Aabenraa, Denmark.
• Br J Surg. 2024 Mar 2; 111 (3).

BackgroundEvidence for the routine use of robotic technology and its impact on short-term outcomes in colon cancer surgery is lacking. The aim of this study was to compare the surgically induced systemic stress response and clinical and patient-reported outcomes for patients undergoing robot-assisted or laparoscopic colon cancer surgery.MethodsIn this double-blinded superiority RCT completed between August 2021 and March 2023, patients with stage 1-3 colon cancer were randomized in a 1 : 1 ratio to undergo either robot-assisted or laparoscopic colon cancer surgery. The primary outcome was changes in the systemic stress response, characterized by C-reactive protein expression in the first three postoperative days. Secondary outcomes were intraoperative and postoperative complications and patient-reported outcomes. The latter included quality of recovery-15 and pain intensity using a visual analogue scale.ResultsIn total, 128 patients were screened for potential inclusion in this study; 50 patients (25 in the robot-assisted group and 25 in the laparoscopic group) were included in the final follow-up and analysis. The postoperative C-reactive protein response was higher on the first postoperative day in the laparoscopic group (mean difference = 19.88 mg/l, 95% c.i. 3.89-35.86; P = 0.045). No statistically significant differences were noted for C-reactive protein expression on the second and third postoperative days.ConclusionAdopting robot-assisted surgery for stage 1-3 colon cancer is associated with a reduction in the surgical stress response.Registration NumberNCT04687384 (http://www.clinicaltrials.gov).© The Author(s) 2024. Published by Oxford University Press on behalf of BJS Foundation Ltd. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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