• Br J Anaesth · Feb 2011

    Case Reports

    Sugammadex in the management of rocuronium-induced anaphylaxis.

    • N J McDonnell, T J G Pavy, L K Green, and P R Platt.
    • School of Women's and Infants' Health, University of Western Australia, Australia. nolan.mcdonnell@health.wa.gov.au
    • Br J Anaesth. 2011 Feb 1;106(2):199-201.

    AbstractAnaphylaxis during anaesthesia is a rare event that in ∼60-70% of cases is secondary to neuromuscular blocking agents. It has been suggested previously that the recent introduction of sugammadex may provide a novel therapeutic approach to the management of rocuronium-induced anaphylaxis. We describe the case of a 33-yr-old female who suffered a severe anaphylactic reaction to rocuronium, presenting with cardiovascular collapse on induction of anaesthesia. After 19 min of traditional management, she was given a bolus of sugammadex 500 mg. This was associated with an improvement in the adverse haemodynamic state. The underlying reasons for this are unclear, but sugammadex may potentially be a useful adjunct in the management of rocuronium-induced anaphylaxis.

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