• Internal medicine · Dec 2024

    Case Reports

    Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma: A Case Report.

    • Satoshi Nakamura, Tomotsugu Takano, Kousei Nakatsuru, Kazuya Tsubouchi, Takuji Yamauchi, Mikiko Hashisako, Takeshi Iwasaki, and Isamu Okamoto.
    • Department of Respiratory Medicine, Kyushu University Hospital, Japan.
    • Intern. Med. 2024 Dec 1; 63 (23): 322732313227-3231.

    AbstractNodal T-follicular helper cell lymphoma (nTFHL), a hematologic neoplasm originating from T-follicular helper (TFH) cells, occasionally presents with pulmonary radiographic abnormalities, without neoplastic cellular infiltration. However, the precise mechanisms underlying non-neoplastic pulmonary opacities in patients with nTFHL remain unclear. Previous reports have shown that TFH cell abnormalities are associated with collagen disease and interstitial pneumonia with autoimmune features (IPAF). We herein report a patient with nTFHL accompanied by interstitial pneumonia diagnosed via lung and lymph node biopsies. These findings suggest the need to rule out nTFHL before diagnosing IPAF.

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