• Raheel Ahmed, Hiroyuki Sawatari, Khadija Amanullah, Joseph Okafor, Syed Emir Irfan Wafa, Saurabh Deshpande, Kamleshun Ramphul, Isma Ali, Mohammed Khanji, Sebastian Mactaggart, Omar AbouEzzeddine, Vasilis Kouranos, Rakesh Sharma, Virend K Somers, Selma F Mohammed, and ChahalC Anwar ACAADepartment of Cardiology, Barts Heart Centre, London, United Kingdom; Northumbria Hospitals NHS Foundation Trust, Newcastle Upon Tyne, United Kingdon; William Harvey Research Institute, Queen Mary University of London, United Kingdom; Ce.
• Cardiac Sarcoidosis Services, Royal Brompton Hospital, London, part of Guys and St Thomas's NHS Trust, London, United Kingdom.
• Am. J. Med. 2024 Apr 6.

BackgroundSarcoidosis is associated with a poor prognosis. There is a lack of data examining the outcomes and readmission rates of sarcoidosis patients with heart failure (SwHF) and without heart failure (SwoHF). We aimed to compare the impact of non-ischemic heart failure on outcomes and readmissions in these two groups.MethodsThe US Nationwide Readmission Database was queried from 2010-2019 for SwHF and SwoHF patients identified using the International Classification of Diseases, Ninth and Tenth Editions. Those with ischemic heart disease were excluded, and both cohorts were propensity matched for age, gender, and Charlson Comorbidity Index (CCI). Clinical characteristics, length of stay, adjusted healthcare-associated costs, 90-day readmission and mortality were analyzed.ResultsWe identified 97,961 hospitalized patients (median age 63 years, 37.9% male) with a diagnosis of sarcoidosis (35.9% SwHF vs. 64.1% SwoHF). On index admission, heart failure patients had higher prevalences of atrioventricular block (3.3% vs. 1.4%, p<0.0001), ventricular tachycardia (6.5% vs. 1.3%, p<0.0001), ventricular fibrillation (0.4% vs. 0.1%, p<0.0001) and atrial fibrillation (22.1% vs. 7.5%, p<0.0001). SwHF patients were more likely to be readmitted (hazard ratio 1.28, p<0.0001), had higher length of hospital stay (5 vs. 4 days, p<0.0001), adjusted healthcare-associated costs ($9,667.0 vs. $9,087.1, p<0.0001) and mortality rates on readmission (5.1% vs. 3.8%, p<0.0001). Predictors of mortality included heart failure, increasing age, male sex, higher CCI and liver disease.ConclusionSwHF is associated with higher rates of arrhythmia at index admission, as well as greater hospital cost, readmission and mortality rates compared to those without heart failure.Copyright © 2024. Published by Elsevier Inc.

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