• Gilnei B da Silva, Daiane Manica, Alana P da Silva, Eduarda Valcarenghi, Sabine R Donassolo, Greicy C Kosvoski, Maiqueli E D Mingoti, Jullye Gavioli, Joana V Cassol, Marceli C Hanauer, Mariélly B Hellmann, Filomena Marafon, Amanda G Bertollo, Jesiel de Medeiros, Arthur D Cortez, Gislaine Z Réus, Gabriela G de Oliveira, Zuleide M Ignácio, and Margarete D Bagatini.
• Multicentric Postgraduate Program in Biochemistry and Molecular Biology, State University of Santa Catarina, Lages, SC, Brazil.
• Am. J. Med. Sci. 2024 Apr 16.

AbstractWe evaluated glycemia and triglyceride, hepatic, muscular, and renal damage markers, redox profile, and leptin and ghrelin hormone levels of COVID-19 patients. We also realized statistical analysis to verify the potential of biomarkers to predict poor prognosis and the correlation between them in severe cases. We assessed glycemia and the levels of triglycerides, hepatic, muscular, and renal markers in automatized biochemical analyzer. The leptin and ghrelin hormones were assessed by the ELISA assay. Severe cases presented high glycemia and triglyceride levels. Hepatic, muscular, and renal biomarkers were altered in severe patients. An oxidative stress status was found in severe COVID-19 patients. Severe cases also had increased levels of leptin. The ROC curves indicated many biomarkers as poor prognosis predictors in severe cases. The Spearman analysis showed that biomarkers correlate between themselves. Patients with COVID-19 showed significant dysregulation in the levels of several peripheral biomarkers. We bring to light that a robust panel of peripheral biomarkers and hormones predict poor prognosis in severe cases of COVID-19, as well as correlates between them. Early monitoring of these biomarkers may conduct the correct clinical intervention associated with the clinical symptoms for treating patients infected by SARS-CoV-2.Copyright © 2024. Published by Elsevier Inc.

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